褪黑素对豚鼠老年性聋的拮抗作用

    发布时间:2015-07-31   来源:中华康网   
前言:目的观察褪黑素对豚鼠老年性聋的拮抗作用。方法80只豚鼠随机分为4组正常对照组(A组),老年性聋模型组(B组),褪黑素治疗的老年性聋模型组(C组0。3mg/(kg。d)和D组1。0mg/(kg。d))。以腹腔注射D-半乳糖制作老年性聋模型,4周后测量各组ABR、耳蜗组织谷胱甘肽-过氧化物酶(GSH-Px)含量,耳蜗铺片观察毛细胞变化情况。结果与A组比较,B、C组ABR阈值、Ⅰ波潜伏期、Ⅲ波潜伏期及Ⅰ、Ⅲ波间期均升高,GSH-Px含量降低(P<0。05或0。01)。D组上述各指标与A组相比,差异无统计学意义(P>0。05)。耳蜗铺片结果,B组耳蜗基底膜各周外毛细胞排列紊乱,大小不一,胞内颗粒染色变浅,可见细胞点状缺失;A、D组外毛细胞排列整齐,无缺失;C组介于B、D组之间。结论褪黑素对老年性聋豚鼠听力及耳蜗毛细胞有保护作用,且与剂量有关。河南省人民医院耳鼻喉科尹志华
    Aim: To investigate the protective effects of melatonin (MT) on presbycusis model. Methods: A total of 80 guinea pigs were divided into four groups: control group (A), presbycusis model group (B), presbycusis model with MT treatment groups(group C: MT 0.3 mg/(kg・d); group D: MT 1.0 mg/(kg・d)). D-galactose was used to induce presbycusis model via intraperitoneal injection. ABR, concentration of GSH-Px in cochlea were measured and hair cells was observed. Results:Compared with group A, threshold value,latent ...
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认识老年性聋 
老年性耳聋是人体老化过程在听觉器官中的表现。老年性聋的出现年龄与发展速度因人而异,其发病机制尚不清楚,似与遗传及整个生命过程中所遭受到的各种有害因素(包括疾病、...
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