摘 要:脑肿瘤细胞生长速率加快,能量代谢、氨基酸转运和蛋白质合成旺盛.联合18F-FDG与11C-MET的PET,比单一显像剂更有助于脑肿瘤的组织学分级、术后复发和疗效评价.11C-MET较1sF-FDG能更精确地显示肿瘤扩散范围和轮廓,对制订手术和立体定向放疗计划有重要意义,是常规CT和(或)MRI的有益补充.
关键词:18F-氟代脱氧葡萄糖;11C-甲硫氨酸;正电子发射体层显像;脑肿瘤;对比研究
分类号:R817.4 文献标识码:A
文章编号:1001-098X(2005)01-0010-05
作者单位:蔡莉(300052,天津医科大学总医院PET-CT中心)
李彦生(300052,天津医科大学总医院PET-CT中心)
参考文献:
[1]Chung JK, Lee YJ, Kim SK, et al. Comparison of[18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer [J]. Nucl Med Commun, 2004, 25(1): 11-17.
[2]Inoue T, Shibasaki T, Oriuchi N, et al. 18F alpha-methyl tyrosine PET studies in patients with brain tumors[J]. J Nucl Med, 1999, 40(3): 399-405.
[3]Laverman P, Boerman OC, Corstens FH, et al. Fluorinated amino acids for tumor imaging with positron emission tomography[J]. Eur J Nucl Med Mol Imaging, 2002, 29(5): 681-690.
[4]Rau FC, Weber WA, Wester HJ, et al. O-(2-[18F]fluoroethyl)-L-tyrosine (FET): a tracer for differentiation of tumour from inflammation in murine lymph nodes[J]. Eur J Nucl Med, 2002, 29(8): 1039-1046.
[5]Becherer A, Karanikas G, Szabo M, et al. Brain tumour imaging with PET: a comparison between [18F]fluorodopa and [11C]methionine[J]. Eur J Nucl Med Mol Imaging, 2003, 30(11): 1561-1567.
[6]Utriainen M, Metsahonkala L, Salmi TT, et al. Metabolic characteri zation of childhood brain tumors: comparison of 18F-fluorodeoxyglucose and 11C-methionine positron emission tomography[J]. Cancer,2002, 95(6): 1376-1386.
[7]Padma MV, Said S, Jacobs M, et al. Prediction of pathology and survival by FDG PET in gliomas[J]. J Neurooncol, 2003, 64(3): 227- 237.
[8]Chung JK, Kim YK, Kim SK, et al. Usefulnes of 11C-methionine PET in the evaluation of brain lesions that are hypo-or isometabolic on 18F-FDG PET [J]. Eur J Nucl Med Mol Imaging, 2002, 29 (2): 176-182.
[9]Narayanan TK, Said S, Mukherjee J, et al. A comparative study on the uptake and incorporation of radiolabeled methionine, choline and fluorodeoxyglucose in human astrocytoma[J]. Mol Imaging Biol,2002, 4(2): 147-156.
[10]Kracht LW, Friese M, Herholz K, et al. Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma[J]. Eur J Nucl Med Mol Imaging, 2003, 30(6): 868-873.
[11]Chao ST, Suh JH, Raja S, et al. The sensitivity and specificity of FDG PET in distinguishing recurrent brain tumor from radionecrosisin patients treated with stereotacitc radiosurgery[J]. Int J Cancer (Radiat Oncol Invest ), 2001, 96(3): 191-197.
[12]Weber WA, Wester HJ, Grosu AL, et al. O-(2-[18F] fluoroethyl)-Ltyrosine and L-[methyl-11C]methionine uptake in brain tumors: initial results of a comparative study[J]. Eur J Nucl Med, 2000, 27(5): 542 -549.
[13]Langen KJ, Jarosch M, Muhlensiepen H, et al. Comparison of fluo rotyrosines and methionine uptake in F98 rat gliomas[J]. Nucl Med Biol, 2003, 30(5): 501-508.
[14]Pirotte B, Goldman S, Massager N, et al. Comparison of 18F-FDG and 11C-methionine for PET-guided stereotactic brain biopsy of gliomas [J]. J Nucl Med, 2004, 45(8): 1293-1298.
[15]Levivier M, Massager N, Wikler D, et al. Use of stereotactic PET images in dosimetry planning of radiosurgery for brain tumors: clinical experience and proposed classification[J]. J Nucl Med, 2004, 45 (7): 1146-1154.
[16]Belohlavek O, Simonova G, Kantorova L, et al. Brain mtastases after stereotactic radiosurgery using the Leksell gamma knife: can FDG PET help to differentiate radionecrosis from tumour progression?[J]. Eur J Nucl Med Mol Imaging, 2003, 30(1): 96-100.
[17]Braga FJHN, Flamen P, Van Calenbergn F. 11C-methionine ( MET )and 18F-FDG PET for the evaluation of suspected recurrent brain tumous(SRBT) [J]. Eur J Nucl Med, 2000, 27(8): 1145.
[18]Langleben DD, Segall GM. PET in differentiation of recurrent brain tumor from radiation injury[J]. J Nucl Med, 2000, 41(11): 1861-1867.
[19]Kim S, Chung JK, Im SH, et al. 11C-methionine PET as a prognostic marker in patients with glioma: comparison with (18)F-FDG PET [J]. EurJ Nucl Med Mol Imaging, 2005, 32( 1 ): 52-59.