中医辨证与肝素治疗对过敏性紫癜肾保护的比较研究

河南中医学院第一附属医院儿科医院肾脏病区河南中医学院第一附属医院儿科翟文生

翟文生  郑伟伟（济源市人民医院儿科） 魏磊(郑州市儿童医院肾内科)

Syndrome differentiation with heparin in the treatme-

nt of children with Henoch-Schonlein purpura in compareative study of renal protection

Zheng wei wei(Pediatrics of Traditional Chinese Medicine)

Directed by Professor Zhai Wen sheng

Abstract

Objective ：Discussion on TCM syndrome differentiation and treatment treatment of children with Henoch-Schonlein purpura the efficacy of TCM treatment observed in the renal injury and the incidence of HSPN preventive effect, and comparison with heparin and renal injury in HSPN role in the incidence of the intensity of prevention.

Methods: Using random and juxtaposed methods, Observing 60 cases of children with Henoch-Schonlein purpura of Henan College of Traditional Chinese Medicine First Affiliated Hospital and Zhengzhou Children\"s Hospital, and in accordance with the diagnostic criteria and inclusion criteria. Using random number table, the patients were randomly divided into two groups. The treatment group: conventional Western medicine and TCM differential treatment; The control group: conventional Western medicine and heparin. By monitoring the Urinary albumin and β2-microglobulin(β2-MG)、Urinary convention、24-hour urinary protein, to observe the incidence of renal injury and Henoch-Schonlein nephritis two groups of children, and 4 weeks after treatment to determine clinical efficacy.

Results:

1. Two groups of children with skin purpura disappeared in time, by two independent samples t test, the treatment group than the control group (P0.05).

2. Treatment group 30 cases, 17 cases fully recovered, 8 cases of markedly effective 2 cases of effective, 3 cases ineffective, the total effective rate 90%; 28 cases in the control group, 16 cases fully recovered, extraordinary effective 6 cases, 4 cases of effective and ineffective in 2 case, the total 92.9% efficient, the two groups by rank sum test, no significant difference (P>0.05).

3. Two groups of children with urinary ALB and urine β2-MG, both before and after treatment significant difference (P0.05).

4. 30 cases of treatment group, there are four cases of renal injury, the incidence rate