骨肉瘤的治疗现状，我们处在十字路口！(转载)
Long-term outcome for patients with high-grade osteosarcoma has improved with the addition of systemic
chemotherapy, but subsequent progress has been less marked. Modern, multiagent, dose-intensive第三军医大学新桥医院骨科张瑗
chemotherapy in conjunction with surgery achieves a 5-year event-free survival of 60C70% in extremity
localized, non-metastatic disease. A major, as yet unsolved, problem is the poor prognosis for metastatic
relapse or recurrence, and for patients with axial disease. This article reviews the current state of the art
of systemic osteosarcoma therapy by focusing on the experiences of cooperative osteosarcoma groups.
Also, we shed light on questions and challenges posed by the aggressiveness of the tumor, and we consider
potential future directions that may be critical to progress in the prognosis of high-grade
osteosarcoma.
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